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Medicines that inhibit CYP2D6 action, for example paroxetine and quinidine, could lead to decreased clearance of oxycodone which could lead on to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Likewise to most other opioids, oxycodone
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Frequently Assess patients, notably when initiating and titrating ROXICODONE and when ROXICODONE is given concomitantly with other medications that depress respiration [see Warnings and Safeguards (five.Tend not to abruptly discontinue ROXICODONE in sufferers who might be physically dependent on opioids. Immediate discontinuation of opioid analgesi